Michael D. West Ph.D.

Scientific Papers

1. West, M.D., Pereira-Smith, O.M., and Smith, J.R. 1989. Replicative Senescence of Human Skin Fibroblasts Correlates with a Loss of Regulation and Overexpression of Collagenase Activity. Experimental Cell Research, 184:138-147.

2. Shay, J.W., West, M.D., Wright, W.E. 1992. Re-expression of Senescent Markers in De-induced Reversibly Immortalized Cells. Exp. Gerontol. 27: 477-492.

3. West, M.D. 1994. The Cellular and Molecular Biology of Skin Aging. Arch. Dermatol. 130: 87-95.

4. Harley, C.B., Kim, N.W., Prowse, K.R., Weinrich, S.L., Hirsch, K.S., West, M.D., Bacchetti, S., Hirte, H.W., Counter, C.M., Greider, C.W., Piatyszek, M.A., Wright, W.E., and Shay, J.W. 1994. Telomerase, Cell Immortality, and Cancer. Cold Spring Harbor Symposium on Quantitative Biology LIX: 307-315. Cold Spring Harbor Press. Cold Spring Harbor, N.Y.

5. Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L.C., Coviello, G.M., Wright, W.E., Weinrich, S.L., and Shay, J.W. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science, 266: 2011-2014.

6. Feng, J., Funk, W.D., Wang, S-S, Weinrich, S.L., Avilion, A.A., Chiu, C-P., Adams, R., Chang, E., Allsopp, R.C., Siyuan Le, J-Y., West, M.D., Harley, C.B., Andrews, W.H., Greider, C.W., Villeponteau, B.V. 1995. The RNA Component of Human Telomerase. Science. 269: 1236-1241.

7. Linskens, M.H., Harley, C.B., West, M.D., Campisi, J., and Hayflick, L. 1995. Replicative Senescence and Cell Death. Science 267 (5194): 17.

8. West, M.D. 1995. Chromosome and Breakage. In The Encyclopedia of Aging. 2nd Edition. Springer, NY. p179.

9. West, M.D., Shay, J.W., Wright, W.E., and Linskens, M.H.K. 1996. Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence. Exp. Gerontol. 31: 175-193.

10. Effros, R.B., Allsopp, R., Chiu, C-P., Hausner, M.A., Hirji, K., Wang, L., Harley, C.B., Villeponteau, B., West, M.D., and Giorgi, J.V. 1996. Shortened telomeres in the expanded CD28- CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10: F17-F22.

11. Vaziri, H., West, M.D., Allsopp, R.A., Davison, T.S., Wu, Y-S., Arrowsmith, C.H., Harley, C.B., Poirier, G.G., and Benchiol., S. 1997. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein through poly(ADP-ribose) polymerase. EMBO J. 16: 6018-6033.

12. West, M.D. 1999. Collagenase and Aging. In: The Collagenases, (Ed. Hoeffler, W.) R.G. Landes Co., Austin, TX, p. 241-254.

13. Matsunaga, H., Handa, J.T., Aotaki-Keen, A., Sherwood, S.W., West, M.D., and Hjelmeland, L.M. 1999. Beta-galactosidase Histostochemistry and Telomere Loss in Senescent Retinal Pigment Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 40:197-202.

14. Lanza, R.P., Arrow, K.J., Axelrod, J., Baltimore, D., Benacerraf, B., Bloch, K.E., Bloembergen, N., Brown, H.C., Brown, M.S., Cibelli, J.B., Cohen, S., Cooper, L.N., Corey, E.J., Dulbecco, R., Fischer, E.H., Fitch, V.L., Friedman, J.L., Friedman, M., Furchgott, R.F., Gell-Mann, M., Glaser, D.A., Glashow, S.L., Gilbert, W., Goldstein, J.L., Gould, S.J., Guillemin, R., Hauptman, H.A., Herschbach, D., Hoffman, R., Hood, L., Hubel, D.H., Karle, J., Klein, L.R., Kohn, W., Kornberg, A., Krebs, E.G., Lederman, L.M., Lederberg, J., Lee, D.M., Lucas, R.E., Marcus, R.A., Merrifield, R.B., Miller, M.H., Modigliani, F., Molina, M.J., Mullis, K., Murad, F., Murray, J.E., Nathans, D., Nirenberg, M.W., North, D.C., Olah, G.A., Palade, G.E., Perl, M.J., Ramsey, N.F., Richter, B., Roberts, R.J., Robl, J.M., Samuelson, P.A., Schwartz, M., Sharp, P.A., Smalley, R.E., Smith, H.O., Solow, R.M., Taube, H., Tonegawa, S., Watson, J.D., Weinberg, S., Weller, T.H., West, M.D., Wieschaus, E.F., Wiesel, T.N., Wilson, R.W. 1999. Science Over Politics. Science, 283: 1849-1850.

15. Lanza, R.P., Cibelli, J.B., and West, M.D. 1999. Prospects for the use of nuclear transfer in human transplantation. Nature Biotechnology 17(12): 1171-1174.

16. Lanza, R.P., Cibelli, J.B., and West, M.D. 1999. Human therapeutic cloning. Nature Medicine 5(9): 975-977.

17. Lanza, R.P., Cibelli, J.B., Blackwell, C., Cristofalo, V.J., Francis, M.K., Baerlocher, G.M., Mak, J., Schertzer, M., Chavez, E.E., Sawyer, N., Lansdorp, P.M., and West, M.D. 2000. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 288: 665-669.

18. Lanza, R.P., Cibelli, J.B., Diaz, F., Moraes, C.T., Farin, P.W., Farin, C.E., Hammer, C.J., West, M.D., and Damiani, P. 2000. Cloning of an endangered species (Bos gaurus) using interspecies nuclear transfer. Cloning 2(2): 79-90.

19. Lanza, R.P., Caplan, A.L., Silver, L.M., Cibelli, J.B., West, M.D., and Green, R.M. 2000. The ethical validity of using nuclear transfer in human transplantation. JAMA 284(24): 3175-3179.

20. Lanza, R.P., Cibelli, J.B., West, M.D., Dorff, E., Tauer, C., and Green, R.M. 2001. The ethical reasons for stem cell research. Science 292(5520): 1299b.

21. Cibelli, J.B., Kiessling, A.A., Cunniff, K., Richards, C., Lanza, R.P., and West, M.D. 2001. Somatic cell nuclear transfer in humans: Pronuclear and early embryonic development, e-biomed: J. Regen. Med. 2: 25-31.

22. Lanza, R.P., Cibelli, J.B., Faber, D., Sweeney, R.W., Henderson, B., Nevala, W., West, M.D., and Wettstein, P.J. 2001. Cloned animals can be healthy and normal. Science 294(5548): 1893-1894.

23. Arrow KJ, Axelrod J, Benacerraf B, Berg P, Bishop JM, Bloembergen N, Brown HC, Cibelli J, Cohen S, Cooper LN, Corey EJ, Cronin JW, Curl R Jr, Dulbecco R, Fischer EH, Fitch VL, Fogel R, Friedman JI, Furchgott RF, Gell-Mann M, Gilbert W, Gilman A, Glaser D, Glashow SL, Green RM, Greengard P, Guillemin R, Hayflick L, Hauptman HA, Heckman JJ, Heeger A, Herschbach D, Hubel DH, Hulse R, Kandel E, Karle J, Klein LR, Kohn W, Kornberg A, Krebs EG, Lanza RP, Laughlin R, Lederman L, Lee DM, Lewis E, Lipscomb W Jr, Marcus RA, McFadden D, Merrifield RB, Merton R, Modigliani F, Molina MJ, Murad F, Nirenberg MW, North DC, Olah GA, Osheroff D, Palade GE, Perl M, Ramsey NF, Richter B, Roberts RJ, Samuelson PA, Schwartz M, Sharp PA, Smalley RE, Smith HO, Solow RM, Stormer H, Taube H, Taylor R, Thomas ED, Tobin J, Tonegawa S, Townes C, Watson JD, Weinberg S, Weller TH, West MD, Wieschaus EF, Wiesel TN, Wilson RW. 2001. Nobel laureates' letter to President Bush. Washington Post. Feb. 22, 2001.

24. Cibelli, J.B., Campbell, K.H., Seidel, G.E., West, M.D., Lanza, R.P. 2002. The health profile of cloned animals. Nature Biotech. 20: 13-14.

25. Lanza, R.P., Cibelli, J.B., and West, M.D. 2002. Transparency in public relations. Nat. Biotechnol. 20: 117-118.

26. Cibelli, J.B., Lanza, R.P., West, M.D., and Ezzell, C. 2002. The first human cloned embryo. Sci. Am. 286: 44-51.

27. Cibelli, J.B., Grant, K.A., Chapman, K.B., Cunniff, K., Worst, T., Green, H.L., Walker, S.J., Gutin, P.H., Vilner, L., Tabar, V., Dominko, T., Kane, J., Wettstein, P.J., Lanza, R.P., Studer, L., Vrana, K.E., and West, M.D. 2002. Parthenogenetic stem cells in nonhuman primates. Science 295: 819.

28. Butler, R.N., Rothman, D., Harman, S.M., Fossel, M., Heward, C.B., Miller, R.A., Olshansky, S.J., Perls, T.T., Rothman, S.M., Warner, H.R., West, M.D., and Wright, W.E. 2002. Is there an anti-aging medicine? J. Gerontol. A. Biol. Sci. 57(9): B333-338. An interdisciplinary workshop of the International Longevity Center – USA. (available at: http://www.ilcusa.org/_lib/pdf/pr20011101.pdf

29. Lanza, R.P., Chung, H.Y., Yoo, J.J., Wettstein, P.J., Blackwell, C., Borson, N., Hofmeister, E., Schuch, G., Shttp://www.ncbi.nlm.nih.gov/pubmed/12089553oker, S., Moraes, C.T., West, M.D., and Atala, A. 2002. Generation of histocompatible tissues using nuclear transplantation. Nature Biotechnology 20(7): 689-696.

30. Vrana, K.E., Hipp, J.D., Goss, A.M., McCool, B.A., Riddle, D.R., Walker, S.J., Wettstein, P.J., Studer, L.P., Tabar, V., Cunniff, K., Chapman, K., Vilner, L., West, M.D., Grant, K.A., and Cibelli, J.B. 2003. Nonhuman primate parthenogenetic stem cells. Proc. Natl. Acad. Sci. USA, 100(suppl. 1): 11911-11916.

31. West, M.D. 2003. Back to Immortality: The Opportunities and Challenges of Therapeutic Cloning. Life Extension 9(11): 63-70.

32. Lanza, R., Chung, Y., West, M.D., and Campbell, K.H. 2003. Comment on “Molecular correlates of primate nuclear transfer failures”. Science, Apr 11;300(5617):297.

33. Lanza, R., Moore, M.A., Wakayama, T., Perry, A.C., Shieh, J-H., Hendrikx, J., Leri, A., Chimenti, S., Monsen, A., Nurzynska, D., West, M.D., Kajstura, J., and Anversa, P. 2004. Regeneration of infarcted heart with stem cells derived by nuclear transplantation. Circ. Res. 94(6): 820-827.

34. Butler, R.N., Warner, H.R., Williams, T.F., Austad, S.N., Brody, J.A., Campisi, J., Cerami, A., Cohen, G., Cristofalo, V.J., Drachman, D.A., Finch, C.E., Fridovich, I., Harley, C.B., Havlik, R.J., Martin, G.M., Miller, R.A., Olshansky, S.J., Pereira-Smith, O.M., Smith, J.R., Sprott, R.L., West, M.D., Wilmoth, J.R., and Wright, W.E. 1994. The aging factor in health and disease: the promise of basic research on aging. Aging Clin. Exp. Res. 16(2): 104-11; discussion 111-2.

35. Klimanskaya, I., Hipp, J., Rezai, K.A., West, M., Atala, A., Lanza, R. 2004. Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning and Stem Cells, 6(3): 217-245.

36. West, M. (2004). "An interview with Michael West. Interviewed by Vicki Glaser." Rejuvenation Res 7(1): 65-70

37. Klimanskaya, I., Chung, Y., Meisner, L., Johnson, J., West, M.D., and Lanza, R. 2005. Human Embryonic Stem Cells Derived Without Feeder Cells. Lancet 365(9467): 4997.

38. Lanza, R., Shieh, J-H., Wettstein, P.J., Sweeney, R.W., Wu, K., Weisz, A., Borson, N., Henderson, B., West, M.D., and Moore, M.A.S. 2005. Long-Term Bovine Hematopoietic Engraftment with Clone-derived Stem Cells. Cloning and Stem Cells, 7(2): 95-106.

39. Wilmut, I., West, M.D., Lanza, R., Gearhart, J.D., Smith, A., Colman, A., Trounson, A., and Campbell, K.H. 2005. Human Embryonic Stem Cells. Science Online December 13.

40. West, M.D. 2007. Mortal and Immortal Cells: Gerontology in the Age of Regenerative Medicine. In: Physiological Basis of Aging and Geriatrics, 4th Edition, Informa Healthcare (Ed. P. Timiras).

41. West, M .D. and Mason, C. 2007. Mapping the human embryome: 1 to 10e13 and all the cells in between. Reg. Med. Jul;2(4):329-33.

42. West, M.D., Sargent, R.G., Long, J., Brown, C., Chu, J-S., Kessler, S., Derugin, N., Sampathkumar, J., Burrows, C., Vaziri, H., Williams, R., Chapman, K.B., Larocca, D., Loring, J.F., and Murai, J. 2008. The ACTCellerate Initiative: large-scale combinatorial cloning of novel human embryonic stem cell derivatives. Reg. Med. 3(3): 287-308.

43. West, M.D. Embryonic Stem Cells: Prospects of Regenerative Medicine for the Treatment of Human Aging. In: The Future of Aging, (Eds. Fahy, G.M., West, M.D., Coles, L.S., and Harris, S.B.) Springer, Berlin, Germany (In Press).

44. Vaziri H, Chapman K, Guigova A, Teichroeb J, Lacher M, Sternberg H, Singec I, Briggs L, Wheeler J, Sampathkumar J, Gonzalez R, Larocca D, Murai J, Snyder E, Andrews W, Funk W, West M.D. 2010. Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming. Regen. Med. March 16 [Epub ahead of print].